A flow reactor process for the synthesis of peptides utilizing immobilized reagents, scavengers and catch and release protocols.
نویسندگان
چکیده
A general flow process for the multi-step assembly of peptides has been developed and this procedure has been used to successfully construct a series of Boc, Cbz and Fmoc N-protected dipeptides in excellent yields and purities, including an extension of the method to enable the preparation of a tripeptide derivative.
منابع مشابه
Multi-step application of immobilized reagents and scavengers: a total synthesis of epothilone C.
The total synthesis of the cytotoxic antitumour natural product epothilone C has provided a stage for the exploitation and further development of immobilized reagent methods. A stereoselective convergent synthetic strategy was applied, incorporating polymer-supported reagents, catalysts, scavengers and catch-and-release techniques to avoid frequent aqueous work-up and chromatographic purification.
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ورودعنوان ژورنال:
- Chemical communications
دوره 46 شماره
صفحات -
تاریخ انتشار 2006